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דף הבית >> ארכיון כנסים >> כנס העמותה להתפתחות הילד2012 >> תקצירים ומצגות מכנס העמותה 2012 >> מושב 11 הפרעות קשב ריכוז והיפראקטיביות פתרונות להפרעה נפוצה >> השפעת מידבקת מתילפנידט (Day trana) על הרגלי שינה בילדים עם ADHD

Effect of Transdermal Methylphenidate Wear Time on Sleep in Children With Attention Deficit Disorder

 
השפעת מידבקת מתילפנידט (Day trana) על הרגלי שינה בילדים עם ADHD
 
Dr. Arie Ashkenasi
 
Sleep disturbances are common among children and adolescents with attention with attention deficit-hyperactivity disorder. The objective of this study was to evaluate the effect of individualizing wear times of the methylphenidate transdermal system on sleep parameters.
In this open-label, randomized trial, 26 children with attention deficit- hyperactivity disorder and sleep disturbances were randomized (following dose optimization) to 1 of 4 groups with different sequences of patch wear times (ie, 9h, 10h, 11h, and 12h per day wear times each for 1 week in different sequences). 
The primary endpoint was sleep latency. Secondary endpoints were total sleep times, sleep quality, and attention deficit-hyperactivity disorder and related symptoms (assessed by the ADHD Rating Scale- IV and Connor's Global Impression-Parent).
A mixed effects regression model evaluated the effect of patch wear time on sleep and symptom measures. There was no significant effect of patch wear time on sleep latency or total sleep time although there was a trend toward improved sleep quality(p=059) with longer patch wear time.
In conclusion, sleep parameters were not adversely by longer methylphenidate transdermal system patch wear times. Thus, if replicated in larger samples, the individualization of patch wear times should be according to the needs and response of the patient.
 
 
 
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